The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite Plasmodium falciparum

The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite Plasmodium falciparum

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Summary: Malaria parasites undergo a complex life cycle in the human host and the mosquito vector.The ApiAP2 family of iphone 14 price texas DNA-binding proteins plays a dominant role in parasite development and life cycle progression.Most ApiAP2 factors studied to date act as transcription factors regulating stage-specific gene expression.Here, we characterized an ApiAP2 factor in Plasmodium falciparum that we termed PfAP2-HC.We demonstrate that PfAP2-HC specifically binds to heterochromatin throughout the genome.

Intriguingly, PfAP2-HC does not bind DNA in vivo and recruitment of PfAP2-HC to heterochromatin is independent of its DNA-binding domain but strictly dependent on heterochromatin protein 1.Furthermore, our results suggest that PfAP2-HC functions neither in the regulation of gene expression nor in heterochromatin formation or maintenance.In summary, our findings reveal PfAP2-HC as a core component of heterochromatin in malaria parasites and identify unexpected properties and substantial functional divergence among the members of the ApiAP2 family of lock shock and barrel art regulatory proteins.